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Our current research focuses mainly on hyperthermophiles, which are microorganisms that grow near 100°C, and on the roles of metals in microbial metabolism. In a basic science project, we are using the archaeon Pyrococcus furiosus, which grows up to 103°C, to study the structure and…
Our research concerns the mechanism and consequences of Ty1 retrotransposition in the budding yeast Saccharomyces. The Ty1 life cycle resembles that of retroviruses except transposition is not infectious. Ty1 GAG and POL genes encode the structural and enzymatic proteins required for…
We study CRISPR-Cas immune systems that protect prokaryotes from viruses and provide research tools for important biotechnology and biomedical applications
CRISPR-Cas systems are recently discovered RNA-based adaptive immune systems that control invasions of viruses and other mobile…
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