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Our research focuses on glioblastoma, one of the most lethal tumor types in both adults and children. Our lab utilizes cutting-edge technologies in both the oncology and stem cell fields to dissect the cellular and molecular mechanisms underlying the development and progression of glioblastoma.…
We are studying how nutrients regulate signaling and transcription by O-GlcNAcylation (OGN). OGN is the addition and removal of N-acetylglucosamine from Ser(The) residues of nuclear, cytoplasmic and mitochondrial proteins. The cycling sugar is analogous to phosphorylation and has extensive…
Antigenic variation in African trypanosomes
Among the parasites we currently study in the laboratory are African trypanosomes, unicellular eukaryotic protozoa that infect the bloodstream of mammals to cause sleeping sickness in equatorial Africa. Trypanosomiasis continues to be a daily…
We study CRISPR-Cas immune systems that protect prokaryotes from viruses and provide research tools for important biotechnology and biomedical applications
CRISPR-Cas systems are recently discovered RNA-based adaptive immune systems that control invasions of viruses and other mobile…
Glycosylation plays a variety of roles in basic biological processes, and alterations in these carbohydrate structures contribute to many human diseases. The mammalian glycome contains extensive structural and functional heterogeneity that can vary temporally and spatially during development and…
We study stem cells in skeletal muscle and adipose (fat) tissues and develop therapeutics for muscular dystrophy, muscle atrophy, obesity, and type 2 diabetes. We use transgenic mice and cultured human cells to model human diseases and identify therapeutic agents/approaches.
My lab is using experimental and computational approaches to study genomic and epigenomic changes occurring during cancer initiation and progression, as well as during normal biological processes such as mammalian genome evolution and cell differentiation. The goal is to understand the roles of…
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