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Our current research focuses mainly on hyperthermophiles, which are microorganisms that grow near 100°C, and on the roles of metals in microbial metabolism. In a basic science project, we are using the archaeon Pyrococcus furiosus, which grows up to…
Bt proteins are used to control pest insects on corn, cotton, rice, and other important crops. Many Bt proteins have been discovered and each one is toxic to a narrow group of insects. Increased use of Bt carries the risk that insects will adapt and become resistant…
The Analytical Service and Training Laboratory at the CCRC has expertise in structural characterization of glycoconjugates including polysaccharides, glycoproteins (Glycomics and Glycoprotemics) and glycolipids using mass spectrometry (MALDI-…
Our laboratory determined that N-glycosylation of a circulating immunoglobulin was required for receptor binding because long-range contacts within the antibody molecule stabilize key residues to form an interface with the receptor. We believe, based on these results…
Stress is a part of life, even on the cellular level. To survive and adapt to stresses such as nutrient deprivation or temperature shock, cells have to alter gene expression, especially protein translation, and alterations in these responses have been implicated in…
Our research focuses on two major areas: 1) functional metabolomics for drug target selection and validation with an emphasis on isoprenoid biosynthesis in the asexual and sexual stages of the malaria parasite, and 2) drug…
The Dailey lab’s research focuses on the enzymes responsible for heme biosynthesis. Current studies involve structure/function investigations of the terminal enzymes of heme biosynthesis and their relationship to the human genetic diseases known as porphyrias,…
Darvill's research focuses on structurally characterizing the five major noncellulosic carbohydrates of plant primary cell walls homogalacturonan, rhamnogalacturonan I and II, xyloglucan, and glucuronoarabinoxylan. Plant primary cell walls control the rate and…
Our research group is interested in how social psychological and sociocultural phenomena influence student learning, development, and success. Our group primarily studies research experiences, including undergraduate and graduate research, as a context for teaching,…
The Edison lab develops new approaches in metabolomics and natural products research. Our primary research tool is NMR spectroscopy, but we regularly collaborate with experts in mass spectrometry. A major focus is on data integration between NMR, MS, and other…
Our research focuses on glioblastoma, one of the most lethal tumor types in both adults and children. Our lab utilizes cutting-edge technologies in both the oncology and stem cell fields to dissect the cellular and molecular mechanisms…
Our research concerns the mechanism and consequences of Ty1 retrotransposition in the budding yeast Saccharomyces. The Ty1 life cycle resembles that of retroviruses except transposition is not infectious. Ty1 GAG and POL genes encode the…
My laboratory is interested in the molecular and biochemical basis of parasitic diseases. We are currently studying African trypanosomes which are important protozoan parasites causing human African sleeping sickness and Nagana in cattle. We have made…
Short Biography: Dr. Haltiwanger received his B.S. in Biology (1980) and Ph.D. in Biochemistry (1986) from Duke University. He went on to do postdoctoral work at Johns Hopkins University School of Medicine, and took his first…
We are studying how nutrients regulate signaling and transcription by O-GlcNAcylation (OGN). OGN is the addition and removal of N-acetylglucosamine from Ser(The) residues of nuclear, cytoplasmic and mitochondrial proteins. The cycling…
We are an inter-disciplinary research group using concepts and techniques from diverse disciplines including biophysics, biochemistry, and bioinformatics to understand how proteins, the molecular machines of life, work. Our current efforts are focused on protein…
Selenocysteine, the 21st amino acid, is found in all three domains of life and is inserted at UGA codons. Nature has sophisticated mechanisms to distinguish canonical UGA stop codons from UGA codons designated for Selenocysteine (Sec) insertion.…
Our laboratory is interested in the mechanism of metalloproteins involved in radical generation and radical-catalyzed chemical conversions. All of the enzymes being investigated have significant roles in metabolic processes that are essential to human health…
I investigate how to support college biology instructors as they incorporate reformed teaching strategies into their practice. Reformed teaching strategies are strategies that have been shown to improve student outcomes, such as conceptual understanding, problem…
The work in my laboratory deals with the biosynthesis of heme and it regulation. Heme is an essential cofactor for almost all living organisms and participates in a variety of reactions including the regulation central metabolic processes, oxygen binding and…
Biosynthesis and Biological Function of Pectin What is Pectin?
The cell wall of plants is a polysaccharide and protein rich macromolecular structure that is essential for plant form and function. It is also the meeting point between…
Research in the Moremen lab focuses on the structure, regulation, and localization of enzymes involved in the biosynthesis, recognition, and catabolism of mammalian glycoproteins. Carbohydrate structures on glycoproteins contribute to many biological recognition…
Dr. Orlando conducts research on using mass spectrometry (MS) to answer biological questions. He also is concerned with developing new methodologies to increase the amount of information obtained from MS experiments and to reduce the quantity of material needed for…
My lab aims to elucidate the mechanism of transporters, flippases, and polymerases involved in bacterial cell wall biosynthesis, unravel how their function influences bacterial adaptation, discover inhibitory molecules for the development of new antimicrobials, and…
Research in the Prestegard laboratory focuses on nuclear magnetic resonance (NMR) methods development and application of those methods to challenging problems involving soluble proteins, membrane proteins, cell-surface carbohydrates, and carbohydrate-protein…
The three dimensional structures of proteins or protein complexes can provide important clues concerning protein function and mechanism of action on a molecular level. The Rose laboratory is interested in using molecular biology coupled with X-ray crystallography and…
Antigenic variation in African trypanosomes
Among the parasites we currently study in the laboratory are African trypanosomes, unicellular eukaryotic protozoa that infect the bloodstream of mammals to cause sleeping sickness in equatorial…
We are using biochemical, cell biological, genetic, and molecular approaches in conjunction with the yeast system to better understand the function of enzymes involved in the production of isoprenylated proteins. Examples of isoprenylated proteins include the Ras…
We study CRISPR-Cas immune systems that protect prokaryotes from viruses and provide research tools for important biotechnology and biomedical applications
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The surfaces of all eukaryotic cells are richly endowed with a diverse array of complex glycoconjugates. Therefore, carbohydrate moieties linked to protein, lipid, and glycosaminoglycan form the interfaces at which cell-cell interactions occur. Consistent with their…
The research of my group focuses on understanding the integral steps in the molecular pathways used by plants to synthesize complex polysaccharides. A key area of interest is development of methods to express and analyze recombinant plant enzymes, which has…
Our research focuses on protein structure and function and protein-protein interactions. We employ an approach combining modern analytical, biophysical and molecular biology techniques, with an emphasis on biomolecular NMR spectroscopy. Our core projects include the…
Application of structural biology tools for the structure-function studies of relevant biological macromolecules, which include RNA polymerases, neurophysins and their hormone complexes, glutathione transferases, glutamine binding protein and complex, aldehyde…
Glycosylation plays a variety of roles in basic biological processes, and alterations in these carbohydrate structures contribute to many human diseases. The mammalian glycome contains extensive structural and functional heterogeneity that can vary…
Our laboratory examines how post-translational modifications (primarily glycosylation) increase functional diversity of proteins. We are focused on congenital disorders of O-glycosylation that includes forms of X-linked intellectual disability (defects in the O…
Research Areas
Oxygen Sensing
In addition to its role in driving oxidative metabolism, ambient O2 levels carry information of great interest to cells of both unicellular and multicellular organisms. For example, O2…
My lab studies the relationship between protein structure and function, and specifically how enzyme activity is regulated. To do this, we use a combination of techniques, including X-ray crystallography, transient and steady state kinetic, sedimentation velocity and…
Research in the Woods group examines the relationship between carbohydrate conformation and biological recognition. Areas of particular interest include carbohydrate antigenicity in immunological events, carbohydrate- processing enzymes, and the development of…
We study stem cells in skeletal muscle and adipose (fat) tissues and develop therapeutics for muscular dystrophy, muscle atrophy, obesity, and type 2 diabetes. We use transgenic mice and cultured human cells to model human diseases and identify therapeutic…
We are using human pluripotent stem cells (human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs)) to differentiate cell types that are affected in diseases of the peripheral nervous system (PNS). Because primary patient PNS cells in…
My lab is using experimental and computational approaches to study genomic and epigenomic changes occurring during cancer initiation and progression, as well as during normal biological processes such as mammalian genome evolution and cell differentiation. The goal…
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