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Stress is a part of life, even on the cellular level. To survive and adapt to stresses such as nutrient deprivation or temperature shock, cells have to alter gene expression, especially protein translation, and alterations in these responses have been implicated in multiple human pathologies,…
Our research concerns the mechanism and consequences of Ty1 retrotransposition in the budding yeast Saccharomyces. The Ty1 life cycle resembles that of retroviruses except transposition is not infectious. Ty1 GAG and POL genes encode the structural and enzymatic proteins required for…
We are using biochemical, cell biological, genetic, and molecular approaches in conjunction with the yeast system to better understand the function of enzymes involved in the production of isoprenylated proteins. Examples of isoprenylated proteins include the Ras family of oncoproteins, Ras-…
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