Seminar: Dr. Roy Goodacre, "Lessons from large-scale metabolic phenotyping"

Metabolomics is a growing discipline that allows the analysis of the thousands of structural different small molecules found within a biological system. These metabolites can be measured using a variety of different analytical approaches and we have developed gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) for this purpose.  I shall provide an overview of metabolomics and lessons learnt from of our large-scale human serum metabolome project where we profiled 1200 healthy individuals. Using these protocols we then went on to profile another ~1200 ageing individuals and identified key metabolic dysregulation which were drivers behind human frailty, which were validated in a further ~760 ageing individuals.

- Dr. Goodacre's personal statement