Labs

Our current research focuses mainly on hyperthermophiles, which are microorganisms that grow near 100°C, and on the roles of metals in microbial metabolism.  In a basic science project, we are using the archaeon Pyrococcus furiosus, which grows up to 103°C, to study the structure and evolution of…
The Dailey lab’s research focuses on the enzymes responsible for heme biosynthesis. Current studies involve structure/function investigations of the terminal enzymes of heme biosynthesis and their relationship to the human genetic diseases known as porphyrias, biochemical characterization of the…
Short Biography:
Dr. Haltiwanger received his B.S. in Biology (1980) and Ph.D. in Biochemistry (1986) from Duke University. He went on to do postdoctoral work at Johns Hopkins University School of Medicine, and took his first independent position as an Assistant Professor in the Department of…
Our laboratory is interested in the mechanism of metalloproteins involved in radical generation and radical-catalyzed chemical conversions. All of the enzymes being investigated have significant roles in metabolic processes that are essential to human health and some of the enzymes have great…
The work in my laboratory deals with the biosynthesis of heme and it regulation. Heme is an essential cofactor for almost all living organisms and participates in a variety of reactions including the regulation central metabolic processes, oxygen binding and transport and reduction/oxidation…
Biosynthesis and Biological Function of Pectin
What is Pectin?
The cell wall of plants is a polysaccharide and protein rich macromolecular structure that is essential for plant form and function. It is also the meeting point between the plant and its symbionts or pathogens. Pectin is a major…
Research in the Moremen lab focuses on the structure, regulation, and localization of enzymes involved in the biosynthesis, recognition, and catabolism of mammalian glycoproteins. Carbohydrate structures on glycoproteins contribute to many biological recognition events during development, oncogenic…
The primary focus of the Pierce laboratory centers on understanding the regulation of intercellular recognition and adhesion, particularly those events that involve protein-oligosaccharide interactions. Almost 20 years ago, observations were made that when vertebrate cells became oncogenically…
We are using biochemical, cell biological, genetic, and molecular approaches in conjunction with the yeast system to better understand the function of enzymes involved in the production of isoprenylated proteins. Examples of isoprenylated proteins include the Ras family of oncoproteins, Ras-related…
The Scott group conducts research in the general areas of biophysical chemistry. Major current research projects include the use of X-ray absorption spectroscopy to study the structure of metals in biological systems, including metal binding sites in metallosensors and metalloregulators, as well as…
We study CRISPR-Cas immune systems that protect prokaryotes from viruses and provide research tools for important biotechnology and biomedical applications
CRISPR-Cas systems are recently discovered RNA-based adaptive immune systems that control invasions of viruses and other mobile genetic…
Functional diversity increases as you go from DNA to RNA to Proteins. The concept of one gene encodes one gene product is no longer valid. One of the principle ways that diversity is increased is through post-translational modifications of proteins.
Using a combination of methodologies, including…
Research Areas
OXYGEN SENSING
In addition to its role in driving oxidative metabolism, ambient O2 levels carry information of great interest to cells of both unicellular and multicellular organisms. For example, O2 regulates gene expression and modulates ion transport across membranes, and cells…
My lab studies the relationship between protein structure and function, and specifically how enzyme activity is regulated. To do this, we use a combination of techniques, including X-ray crystallography, transient and steady state kinetic, sedimentation velocity and other biophysical tools.  Major…